Publications 2019 – 2014

2019| 20182017 | 2016 | 2015 | 2014 | 2013 thru 2010 | 2009 thru 2006 | 2005 thru 2001 |


Martinez-Quintanilla J, Seah I, Chua M, Shah K. Oncolytic viruses: overcoming translational challenges. Journal of Clinical Investigation 2019 doi: 10.1172/JCI122287. PMID: 30829653

Tanaka S, Luk S, Iafrate AJ, Shah K, Martuza RL, Rabkin SD, Batchelor TT, Cahill DP, Chi AS, Wakimoto H. Genetically distinct glioma stem-like cell xenografts established from paired glioblastoma samples harvested before and after molecularly targeted therapy. Scientific Reports 2019 doi: 10.1038/s41598-018-37437-2. PMID: 30644426

Passaro, C, Alayo, Q, DeLaura, I, McNulty, JJ, Grauwet, K, Ito, H, Bhaskaran, V, Mineo, M, Lawler, SE, Shah K, Speranza, MC, Goins, WF, McLaughlin, E, Fernandez, S, Reardon, DA, Freeman, GJ, Chiocca, EA, Nakashima, H. Arming an oncolytic herpes simplex virus type 1 with a single chain variable antibody against PD-1 for experimental glioblastoma therapy. Clinical Cancer Research 2019 doi: 10.1158/1078-0432.CCR-18-2311. PMID: 30279232


Kuruppu D, Bhere D, Shah K, Farrar C, Brownell AL, Tanabe, KK. A model of breast cancer meningeal metastases: characterization with in vivo molecular imaging. Cancer Gene Therapy 2018 doi: 10.1038/s41417-018-0060-z. PMID: 30420717

Reinshagen C, Bhere D, Choi SH, Hutten S, Nesterenko I, Wakimoto H, Le Roux E, Rizvi A, Du W, Minucci, Shah K. CRISPR-enhanced engineering of therapy-sensitive cancer cells for self-targeting of primary and metastatic tumors. Science Translational Medicine. 2018 Jul 11. doi: 10.1126/scitranslmed.aao3240. PMID: 29997250

Heidari P, Kunawudhi A, Martinez-Quintanilla J, Szretter A, Shah K, Mahmood U. Somatostatin receptor type 2 as a radiotheranostic PET reporter gene for oncologic interventions. Theranostics. 2018 May 23. doi: 10.7150/thno.24017. PMID: 29930736

Bhere D, Khajuria RK, Hendriks WT, Bandyopadhyay A, Bagci-Onder T, Shah K. Therapeutic Neural Stem Cells Engineered During Different Stages of Reprogramming Reveal Varying Therapeutic Efficacies. Stem Cells. 2018 Feb 16. doi: 10.1002/stem.2805. PMID: 29451340

Bhere D, Tamura K, Wakimoto H, Choi SH, Purow B, Debatisse J, Shah K. microRNA-7 upregulates death receptor 5 and primes resistant brain tumors to caspase-mediated apoptosis. Neuro Oncolology. 2018 Jan 22;20(2):215-224. doi: 10.1093/neuonc/nox138. PMID: 29016934


Lobbardi, R., Pinder, P., Martinez-Pastor, B., Blackburn, JS., Abraham, BJ., Mansour, M., Abdelfattah, NS., Molodtsov, A., Toiber, D., Waard, M., Jain, E., Shah, K., Stegmaier, K., Sadreyev, RI., Asara, JM., Look, AT., Young, RA., Mostoslavsky, R., Dellaire, G., Langenau,   TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia.  Cancer Discovery. 2017 doi: 10.1158/2159-8290.CD-17-0267 PMID: 28974511

Choi SH, Stuckey DW, Pignatta S, Reinshagen C, Khalsa JK, Roozendaal NC, Martinez-Quintanilla J, Tamura K, Keles E, Shah K. Tumor Resection Recruits Effector T Cells and Boosts Therapeutic Efficacy of Encapsulated Stem Cells Expressing IFNβ in Glioblastomas. Clinical Cancer Research. 2017 Sep 14. pii: clincanres.0077.2017. doi: 10.1158/1078-0432.CCR-17-0077. PMID: 28912136

Du W, Seah I, Bougazzoul O, Choi G, Meeth K, Bosenberg MW, Wakimoto H, Fisher D, Shah K. Stem cell-released oncolytic herpes simplex virus has therapeutic efficacy in brain metastatic melanomas. PNAS  U S A. 2017 Jul 14. pii: 201700363. doi: 10.1073/pnas.1700363114. PMID: 28710334

Ignatius MS, Hayes MN, Lobbardi R, Chen EY, McCarthy KM, Sreenivas P, Motala Z, Durbin AD, Molodtsov A, Reeder S, Jin A, Sindiri S, Beleyea BC, Bhere D, Alexander MS, Shah K, Keller C, Linardic CM, Nielsen PG, Malkin D, Khan J, Langenau DM. The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma. Cell Reports 2017 Jun 13;19(11):2304-2318. doi: 10.1016/j.celrep.2017.05.061. PMID: 28614716

Zhu Y, Bassoff N, Reinshagen C, Bhere D, Nowicki MO, Lawler SE, Roux J, Shah K. Bi-specific molecule against EGFR and death receptors simultaneously targets proliferation and death pathways in tumors. Scientific Reports. 2017 Jun 1;7(1):2602. doi: 10.1038/s41598-017-02483-9. PMID: 28572590

Jahan N, Lee JM, Shah K, Wakimoto H. Therapeutic targeting of chemoresistant and recurrent glioblastoma stem cells with a proapoptotic variant of oncolytic herpes simplex virus. International Journal of Cancer. 2017  doi: 10.1002/ijc.30811. PMID: 28567859


Choi, SH and Shah, K Engineered bifunctional proteins and stem cells: Next generation of targeted cancer therapeutics Discovery Medicine 2016; 22:157-166. PMID: 27755970

Shah K. Stem cell-based therapies for tumors in the brain: are we there yet? Neuro Oncology. 2016 Jun 9. pii: now096. PMID: 27282399


Zhu, Y., Choi, SH. and Shah, K. Multifunctional receptor-targeting antibodies for cancer therapy. Lancet Oncology. 2015; Nov;16(15):e543-54. doi: 10.1016/S1470-2045(15)00039-X. PMID: 26545843

Wehrenberg-Klee, E., Redjal, N., Leece, A., Turker, N.S., Heidari, P.,Shah, K., Mahmood U.PET imaging of glioblastoma multiforme EGFR expression for therapeutic decision guidance.American Journal of Nuclear Medicine and Molecular Imaging. 2015 Jun 15;5(4):379-89. PMID: 26269775

Bhere, D.,Shah, K. Stem Cell-Based Therapies for Cancer. Advances in Cancer Research. 2015;127:159-89. doi: 10.1016/bs .acr.2015.04.012. Epub 2015 May 19. PMID: 26093900

Bagci-Onder, T., Du, W., Figueiredo, Martinez-Quintanilla, J., and Shah, K. Targeting breast to brain metastatic tumors with death receptor ligand expressing therapeutic stem cells. BRAIN 2015 Jun;138(Pt 6):1710-21. doi:10.1093/brain/awv094. PMID: 25910782

Choi, SH., Tamura, K., Khajuria, R., Lawler, J., and Shah, K. Antiangiogenic variant of TSP-1 targets TRAIL resistance in brain tumors. Molecular Therapy. 2015, 23(2):235-43. doi: 10.1038/mt.2014.214. PMID: 25358253

Martinez-Quintanilla, J., He, D., Wakimoto, H, Alemany, R and Shah, K. Encapsulated stem cells loaded with hyaluronidase-expressing oncolytic virus for brain tumor therapy. Molecular Therapy 2015; 23:108-18 doi: 10.1038/mt.2014.204. PMID: 25352242 

Stuckey, D., Hingtgen, S.D., Karakas, N., Rich, B. and Shah, K. Engineering toxin-resistant therapeutic stem cells to treat brain tumors. Stem Cells. 2015; 33:589-600. doi: 10.1002/stem.1874. PMID: 25346520

Redjal, N., Zhu, Y. and Shah, K. Combination of systemic chemotherapy with local stem cell delivered S-TRAIL in resected brain tumors. Stem Cells. 33(1):101-10. doi: 10.1002/stem.1834. PMID: 25186100


Martinez-Quintanilla, J., Shah K. Response to “Stem cells loaded with multimechanistic oncolytic herpes simplex virus variants for brain tumor therapy.” Journal of the National Cancer Institute. 2014 Dec 2;107(1):370. doi: 10.1093/jnci/dju370.  PMID: 25473105

Stuckey, DW., and Shah, K. Therapeutic stem cells for cancer. Nature Reviews Cancer. 2014 Oct;14(10):683-91. doi: 10.1038/nrc3798. PMID: 25176333.

Sullivan, J.P., Nahed, B.V., Madden, M.W., Oliveira, S.M., Springer, S., Bhere, D., Chi, A.S., Wakimoto, H., Kapur,R., Shah, K., Iafrate, J.A.,, Curry, W.T., Loeffler, J.S., Batchelor, T.T., Louis, D.N., Toner, M., Maheswaran, S. and Haber, D.A. Brain Tumor Cells in Circulation Are Enriched for Mesenchymal Gene Expression.Cancer Discovery. 2014 Aug 19.  PMID: 25139148

Srivastava, J., Robertson, CL., Rajasekaran, D., Gredler, R., Siddiq, A., Emdad, L., Mukhopadhyay, ND., Ghosh, S., Hylemon, PB., Gil, G., Bhere, D., Shah, K., Subler, MA., Windle, JJ., Fisher, PB and Sarkar, D. AEG-1 regulates retinoid X receptor and inhibits retinoid signaling. Cancer Research. 2014 Aug 15;74(16):4364-77. doi: 10.1158/0008-5472. PMID: 25125681

Kuruppu D, Brownell AL, Shah K, Mahmood U, Tanabe KK. Molecular imaging with bioluminescence and PET reveals viral oncolysis kinetics and tumor viability. Cancer Research. 2014 May 29. pii: canres.3472.2013.  PMID: 24876106

Duebgen, M., Martinez-Quintanilla, J., Tamura, K., Hingtgen, S., Redjal, N., Wakimoto, H and Shah, K. Stem Cells Loaded With Multimechanistic Oncolytic herpes simplex virus variants for brain tumor therapy. Journal of National Cancer Institute 2014  May 16 ;106(6):dju090. doi: 10.1093/jnci/dju090. PMID: 24838834

Du, W, Uslar, L., Sevala, S. and Shah, K. Targeting c-Met receptor overcomes TRAIL-resistance in brain tumors. PLoS One. 2014 Apr 18;9(4):e95490. doi: 10.1371/journal.pone.0095490. PMID: 24748276

Zhu, Y and Shah, K. Multiple lesions in receptor tyrosine kinase pathway determine glioblastoma response to pan-ERBB inhibitor PF-00299804 and PI3K/mTOR dual inhibitor PF-05212384. Cancer Biology and Therapy. 2014 Jun 1;15(6):815-22. doi: 10.4161/cbt.28585. PMID: 24658109

Shah, K. Mesenchymal Stem Cells in Cancer Therapy. Elsevier. 2014 Jan 8; eBook ISBN: 9780124166653