Publications

2021| 2020| 2019| 20182017 thru 2015 | 2014 thru 2010 | 2009 thru 2005 | 2004 thru 2001 |

2021

Kiyokawa J, Kawamura Y, Ghouse SM, Acar S, Barçın E, Martínez-Quintanilla J, Martuza RL, Alemany R, Rabkin SD, Shah K, Wakimoto H. Modification of Extracellular Matrix Enhances Oncolytic Adenovirus Immunotherapy in Glioblastoma. Clin Cancer Res. 2021 Feb 1;27(3):889-902. doi: 10.1158/1078-0432.CCR-20-2400. Epub 2020 Nov 30. PMID: 33257429; PMCID: PMC7854507.

Akter F, Simon B, de Boer NL, Redjal N, Wakimoto H, Shah K. Pre-clinical tumor models of primary brain tumors: Challenges and opportunities. Biochim Biophys Acta Rev Cancer. 2021 Jan;1875(1):188458. doi: 10.1016/j.bbcan.2020.188458. Epub 2020 Oct 23. PMID: 33148506; PMCID: PMC7856042.

Aldrak N, Alsaab S, Algethami A, Bhere D, Wakimoto H, Shah K, Alomary MN, Zaidan N. Oncolytic Herpes Simplex Virus-Based Therapies for Cancer. Cells. 2021 Jun 18;10(6):1541. doi: 10.3390/cells10061541. PMID: 34207386; PMCID: PMC8235327.

Ishii Y, Kolluri KK, Pennycuick A, Zhang X, Nigro E, Alrifai D, Borg E, Falzon M, Shah K, Kumar N, Janes SM. BAP1 and YY1 regulate expression of death receptors in malignant pleural mesothelioma. J Biol Chem. 2021 Sep 29;297(5):101223. doi: 10.1016/j.jbc.2021.101223. Epub ahead of print. PMID: 34597666.

Karakaş N, Stuckey D, Revai-Lechtich E, Shah K. IL13Rα2‑ and EGFR‑targeted pseudomonas exotoxin potentiates the TRAIL‑mediated death of GBM cells. Int J Mol Med. 2021 Jul;48(1):145. doi: 10.3892/ijmm.2021.4978. Epub 2021 Jun 3.PMID: 34080646

Tawfik EA, Aldrak NA, Albrahim SH, Alzahrani DA, Alfassam HA, Alkoblan SM, Almalik AM, Chen KS, Abou-Khalil R, Shah K, Zaidan NM. Immunotherapy in hematological malignancies: recent advances and open questions. Immunotherapy. 2021 Oct;13(14):1215-1229. doi: 10.2217/imt-2021-0065. Epub 2021 Sep 9. PMID: 34498496.

Van Schaik TA, Chen KS, Shah K. Therapy-Induced Tumor Cell Death: Friend or Foe of Immunotherapy? Frontiers Oncology 2021 doi.org/10.3389/fonc.2021.678562

Vaughan HJ, Zamboni CG, Radant NP, Bhardwaj P, Revai Lechtich E, Hassan LF, Shah K, Green JJ. Poly(beta-amino ester) nanoparticles enable tumor-specific TRAIL secretion and a bystander effect to treat liver cancer. Mol Ther Oncolytics. 2021 Apr 16;21:377-388. doi: 10.1016/j.omto.2021.04.004. PMID: 34189258; PMCID: PMC8208964.

Cingöz A, Ozyerli-Goknar E, Morova T, Seker-Polat F, Esai Selvan M, Gümüş ZH, Bhere D, Shah K, Solaroglu I, Bagci-Onder T. Generation of TRAIL-resistant cell line models reveals distinct adaptive mechanisms for acquired resistance and re-sensitization. Oncogene. 2021 May;40(18):3201-3216. doi: 10.1038/s41388-021-01697-6. Epub 2021 Mar 25. PMID: 33767436.

Kitamura Y, Kanaya N, Moleirinho S, Du W, Reinshagen C, Attia N, Bronisz A, Revai Lechtich E, Sasaki H, Mora JL, Brastianos PK, Falcone JL, Hofer AM, Franco A, Shah K. Anti-EGFR VHH-armed death receptor ligand-engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers. Sci Adv. 2021 Mar 3;7(10):eabe8671. doi: 10.1126/sciadv.abe8671. Print 2021 Mar. PMID: 33658202

Khalsa JK, Shah K. Immune Profiling of Syngeneic Murine and Patient GBMs for Effective Translation of Immunotherapies. Cells. 2021 Feb 25;10(3):491. doi: 10.3390/cells10030491. PMID: 33668856

López Vázquez M, Du W, Kanaya N, Kitamura Y, Shah K. Next-Generation Immunotherapies for Brain Metastatic Cancers. Trends Cancer. 2021 Mar 12:S2405-8033(21)00045-5. doi: 10.1016/j.trecan.2021.02.003. Epub ahead of print. PMID: 33722479.

Song N, Wakimoto H, Rossignoli F, Bhere D, Ciccocioppo R, Chen KS, Khalsa JK, Mastrolia I, Samarelli AV, Dominici M, Shah K. Mesenchymal stem cell immunomodulation: In pursuit of controlling COVID-19 related cytokine storm. Stem Cells. 2021 Feb 14. doi: 10.1002/stem.3354. Online ahead of print. PMID: 33586320

Jiang L, Jung S, Zhao J, Kasinath V, Ichimura T, Joseph J, Fiorina P, Liss AS, Shah K, Annabi N, Joshi N, Akama TO, Bromberg JS, Kobayashi M, Uchimura K, Abdi R. Simultaneous targeting of primary tumor, draining lymph node, and distant metastases through high endothelial venule-targeted delivery. Nano Today. 2021 Feb;36:101045. doi: 10.1016/j.nantod.2020.101045. PMID: 33391389

2020

Akter F, Simon B, de Boer NL, Redjal N, Wakimoto H, Shah K. Pre-clinical tumor models of primary brain tumors: Challenges and opportunities. Biochim Biophys Acta Rev Cancer. 2020 Oct 23;1875(1):188458. doi: 10.1016/j.bbcan.2020.188458. Online ahead of print. PMID: 33148506

Jiang L, Wang YJ, Zhao J, Uehara M, Hou Q, Kasinath V, Ichimura T, Banouni N, Dai L, Li X, Greiner DL, Shultz LD, Zhang X, Sun ZJ, Curtin I, Vangos NE, Yeoh ZC, Geffken EA, Seo HS, Liu ZX, Heffron GJ, Shah K, Dhe-Paganon S, Abdi R. Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy. Cell. 2020 Nov 25;183(5):1219-1233.e18. doi: 10.1016/j.cell.2020.10.045. PMID: 33242418

Kiyokawa J, Kawamura Y, Ghouse SM, Acar S, Barçın E, Martínez-Quintanilla J, Martuza RL, Alemany R, Rabkin SD, Shah K, Wakimoto H. Modification of Extracellular Matrix Enhances Oncolytic Adenovirus Immunotherapy in Glioblastoma. Clin Cancer Res. 2020 Nov 30. doi: 10.1158/1078-0432.CCR-20-2400. Online ahead of print. PMID: 33257429

Yang EY, Shah K. Nanobodies: Next Generation of Cancer Diagnostics and Therapeutics. Frontiers in Oncology 2020 Jul 23;10:1182. doi: 10.3389/fonc.2020.01182.. PMID: 32793488

Khalsa JK, Cheng N, Keegan J, Chaudry A, Driver J, Bi WL, Lederer J, Shah, K. Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types. Nature Communication 2020 Aug 6;11(1):3912. doi: 10.1038/s41467-020-17704-5. PMID: 32764562

Deng D, Shah K. TRAIL of hope meeting resistance in cancer. Trends in Cancer 2020 Jul 24;S2405-8033(20)30190-4. doi: 10.1016/j.trecan.2020.06.006. PMID: 32718904

Song N, Scholtemeijer M, Shah K. Mesenchymal Stem Cell Immunomodulation: Mechanisms and Therapeutic Potential. Trends in Pharmacological Sciences 2020 Jul 22;S0165-6147(20)30145-0. doi: 10.1016/j.tips.2020.06.009. PMID: 32709406

Levy O, Kuai R, Siren E, Bhere D, Milton Y, Nissar N, De Biasio M, Heinelt M, Reeve B, Abdi R, Alturki M, Fallatah M, Almalik A, Alhasan AH, Shah K*,  Karp JM. Shattering barriers toward clinically meaningful MSC therapies. Science Advances 2020 Jul 22;6(30):eaba6884. doi: 10.1126/sciadv.aba6884.  * Co-corresponding author. PMID: 32832666

Mineo M, Lyons SM, Zdioruk M, von Spreckelsen N, Ferrer-Luna R, Ito H, Alayo QA, Kharel P, Giantini Larsen A, Fan WY, Auduong S, Grauwet K, Passaro C, Khalsa JK, Shah K, Reardon DA, Ligon KL, Beroukhim R, Nakashima H, Ivanov P, Anderson PJ, Lawler SE, Chiocca EA. Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed From the PD-L1 Locus. Molecular Cell2020 Jun. 18. doi: 10.1016/j.molcel.2020.05.015. PMID: 32504554

Karakas N, Bay S, Türkel N, Öztunç N, Öncül M, Bilgen H, Shah K, Şahin F, Öztürk, G. Neurons from human mesenchymal stem cells display both spontaneous and stimuli responsive activity. PLoS One. 2020 May 14. doi: 10.1371/journal.pone.0228510. PMID: 32407317

Lee YH, Pang SW, Révai Lechtich E, Shah K, Simon SE, Ponnusamy S, Narayanan R, Poh CL, Tan KO. Tricistronic expression of MOAP-1, Bax and RASSF1A in cancer cells enhances chemo-sensitization that requires BH3L domain of MOAP-1. Journal of Clinical Research and Clinical Oncology. 2020 May 6. doi: 10.1007/s00432-020-03231-9. PMID: 32377840

Bhere D, Arghiani N, Révai Lechtich E, Yao Y, Alsaab S, Bei F, Matin MM, Shah K. Simultaneous downregulation of miR-21 and upregulation of miR-7 has anti-tumor efficacy. Scientific Reports. 2020 Feb. 4. doi: 10.1038/s41598-020-58072-w. PMID: 32019988

Yang Q, Luo C, Zhang X, Liu Y, Wang Z, Cacciamani P, Shi J, Cui Y, Wang C, Sinha B, Peng B, Tong G, Das G, Shah E, Gao Y, Li W, Tu Y, Qian D, Shah K, Akbar M, Zhou S, Song BJ, Wang X. Tartary buckwheat extract alleviates alcohol-induced acute and chronic liver injuries through the inhibition of oxidative stress and mitochondrial cell death pathway. American Journal of Translational Research2020 Jan. 15. e-collection PMID: 32051738

Kavari SL, Shah K. Concise Review: Engineered Stem Cells Targeting Multiple Cell Surface Receptors in Tumors. Stem Cells 2020 Jan. doi: 10.1002/stem.3069. PMID: 31381835

2019

Kuruppu D, Bhere D, Farrar CT, Shah K, Brownell AL, Tanabe KK. A model of breast cancer meningeal metastases: characterization with in vivo molecular imaging. Cancer Gene Therapy 2019 May 26. doi: 10.1038/s41417-018-0060-z PMID: 30420717

Martinez-Quintanilla J, Seah I, Chua M, Shah K. Oncolytic viruses: overcoming translational challenges. Journal of Clinical Investigation 2019 Mar. 4. doi: 10.1172/JCI122287. PMID: 30829653

Tanaka S, Luk S, Kiyokawa J, Onozato ML, Iafrate AJ, Shah K, Martuza RL, Rabkin SD, Batchelor TT, Cahill DP, Chi AS, Wakimoto H. Genetically distinct glioma stem-like cell xenografts established from paired glioblastoma samples harvested before and after molecularly targeted therapy. Scientific Reports 2019 Jan. 15. doi: 10.1038/s41598-018-37437-2. PMID: 30644426

Passaro, C, Alayo Q, De Laura I, McNulty J, Grauwet K, Ito H, Bhaskaran V, Mineo M, Lawler SE, Shah K, Speranza MC, Goins W, McLaughlin E, Fernandez S, Reardon DA, Freeman GJ, Chiocca EA, Nakashima H. Arming an oncolytic herpes simplex virus type 1 with a single chain variable antibody against PD-1 for experimental glioblastoma therapy. Clinical Cancer Research 2019 Jan. 1. doi: 10.1158/1078-0432.CCR-18-2311. PMID: 30279232

2018

Reinshagen C, Bhere D, Choi SH, Hutten S, Nesterenko I, Wakimoto H, Le Roux E, Rizvi A, Du W, Minicucci C, Shah K. CRISPR-enhanced engineering of therapy-sensitive cancer cells for self-targeting of primary and metastatic tumors. Science Translational Medicine. 2018 Jul. 11. doi: 10.1126/scitranslmed.aao3240. PMID: 29997250

Bhere D, Khajuria RK, Hendriks WT, Bandyopadhyay A, Bagci-Onder T, Shah K. Therapeutic Neural Stem Cells Engineered During Different Stages of Reprogramming Reveal Varying Therapeutic Efficacies. Stem Cells. 2018 Jun. doi: 10.1002/stem.2805. PMID: 29451340

Heidari P, Kunawudhi A, Martinez-Quintanilla J, Szretter A, Shah K, Mahmood U. Somatostatin receptor type 2 as a radiotheranostic PET reporter gene for oncologic interventions. Theranostics. 2018 May 23. doi: 10.7150/thno.24017. PMID: 29930736

Bhere D, Tamura K, Wakimoto H, Choi SH, Purow B, Debatisse J, Shah K. microRNA-7 upregulates death receptor 5 and primes resistant brain tumors to caspase-mediated apoptosis. Neuro Oncolology. 2018 Jan 22. doi: 10.1093/neuonc/nox138. PMID: 29016934

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