Center for Stem Cell and Translational Immunotherapy (CSTI)

Brigham and Women's Hospital, Harvard Medical School

Publications 2014 – 2010

2020 thru 2018 | 2017 thru 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 thru 2005 | 2004 thru 2001 


Stuckey DW and Shah K. Stem Cell-Based Therapies for Cancer Treatment: Separating Hope From Hype. Nature Reviews Cancer. 2014 doi: 10.1038/nrc3798. PMID: 25176333.

Sullivan JP, Nahed BV, Madden MW, Oliveira SM, Springer S, Bhere D, Chi AS, Wakimoto H, Kapur R, Shah K, Iafrate JA, Curry WT, Loeffler JS, Batchelor TT, Louis DN, Toner M, Maheswaran S and Haber DA. Brain Tumor Cells in Circulation Are Enriched for Mesenchymal Gene Expression. Cancer Discovery. 2014 doi: 10.1158/2159-8290.CD-14-0471. PMID: 25139148

Martinez-Quintanilla J and Shah K. Response to “Stem cells loaded with multimechanistic oncolytic herpes simplex virus variants for brain tumor therapy.” Journal of the National Cancer Institute. 2014 doi: 10.1093/jnci/dju370.  PMID: 25473105

Duebgen M, Martinez-Quintanilla J, Tamura K, Hingtgen S, Redjal N, Wakimoto H and Shah K. Stem Cells Loaded With Multimechanistic Oncolytic herpes simplex virus variants for brain tumor therapy. Journal of National Cancer Institute 2014 doi: 10.1093/jnci/dju090. PMID: 24838834

Kuruppu D, Brownell AL, Shah K, Mahmood U and Tanabe KK. Molecular imaging with bioluminescence and PET reveals viral oncolysis kinetics and tumor viability. Cancer Research. 2014 doi: 10.1158/0008-5472.CAN-13-3472.  PMID: 24876106

Srivastava J, Robertson CL, Rajasekaran D, Gredler R, Siddiq A, Emdad L, Mukhopadhyay ND, Ghosh S, Hylemon PB, Gil G, Shah K, Bhere D, Subler MA, Windle JJ, Fisher PB and Sarkar D. AEG-1 regulates retinoid X receptor and inhibits retinoid signaling. Cancer Research. 2014 doi: 10.1158/0008-5472. PMID: 25125681

Zhu Y and Shah K. Multiple lesions in receptor tyrosine kinase pathway determine glioblastoma response to pan-ERBB inhibitor PF-00299804 and PI3K/mTOR dual inhibitor PF-05212384. Cancer Biology and Therapy. 2014 doi: 10.4161/cbt.28585. PMID: 24658109

Du W, Uslar L, Sevala S and Shah K. Targeting c-Met receptor overcomes TRAIL-resistance in brain tumors. PLoS One. 2014  doi: 10.1371/journal.pone.0095490. PMID: 24748276

Shah K. Mesenchymal Stem Cells in Cancer Therapy. Elsevier. 2014 eBook ISBN: 9780124166653.


Shah K. Stem Cell Therapeutics for Cancer. Wiley-Blackwell 2013 ISBN: 978-1-118-28242-7

Stuckey DW and Shah K. TRAIL on Trial: Preclinical Advances in Cancer Therapy. Trends in Molecular Medicine. 2013 doi: 10.1016/j.molmed.2013.08.007. PMID: 24076237

Bagci-Onder T, Agarwal A, Flusberg D, Wanningen S, Sorger P and Shah K. Real time imaging of the dynamics of death receptors and therapeutics that overcome TRAIL resistance in tumors. Oncogene. 2013 doi: 10.1038/onc.2012.304. PMID: 22824792

Tamura K, Wakimoto H, Agarwal A, Rabkin SD, Bhere D, Martuza RL, Kuroda T, Kasmieh R and Shah K. Multi-mechanistic tumor targeted oncolytic virus overcomes resistance in brain tumors. Molecular Therapy. 2013 doi: 10.1038/mt.2012.175. PMID: 22929661.

Martinez-Quintanilla J, Bhere D, Heidari P, He D, Mahmood U and Shah K. Therapeutic efficacy and fate of bimodal engineered stem cells in malignant brain tumors. Stem Cells. 2013 doi: 10.1002/stem.1355. PMID: 23389839

Shah K. Encapsulated stem cells for cancer therapy. Biomatter. 2013 doi: 10.4161/biom.24278. PMID: 23507920

Guo Y, Yuan H, Cho H, Kuruppu D, Jokivarsi K, Agarwal A, Shah K, Josephson L. High Efficiency Diffusion Molecular Retention Tumor Targeting. PLoS One 2013 doi: 10.1371/journal.pone.0058290. PMID: 23505478

Hingtgen S, Figueiredo JL, Farrar C, Duebgen M, Martinez-Quintanilla J, Bhere D and Shah K. Real-time multi-modality imaging of glioblastoma tumor resection and recurrence. Journal of Neuro-Oncology. 2013 doi: 10.1007/s11060-012-1008-z PMID: 23242736


Shah K. Mesenchymal Stem Cells Engineered for Cancer Therapy. Advanced Drug Delivery Reviews. 2012 doi: 10.1016/j.addr.2011.06.010. PMID: 21740940

Srivastava J, Robertson CL, Rajasekaran D, Gredler R, Siddiq A, Emdad L, Mukhopadhyay ND, Ghosh S, Hylemon PB, Gil G, Shah K, Bhere D, Subler MA, Windle JJ, Fisher PB and Sarkar D. Astrocyte Elevated gene-1 Promotes Hepatocarcinogenesis: Novel Insights From a Mouse Model. Hepatology. 2012 doi: 10.1002/hep.25868. PMID: 22689379

Van de Water JA, Bagci-Onder T, Agarwal AS, Wakimoto H, Roovers RC, Zhu Y, Kasmieh R, Bhere D, Van Bergen En Henegouwen PM and Shah K. Therapeutic stem cells expressing variants of EGFR-specific nanobodies have antitumor effects. PNAS. 2012 doi: 10.1073/pnas.1202832109. PMID: 23012408

Nesterenko I, Wanningen S, Bagci-onder T, Anderegg M and Shah K. Evaluating the effect of therapeutic stem cells on TRAIL resistant and sensitive medulloblastomas. 2012 PLoS ONE. doi: 10.1371/journal.pone.0049219. PMID: 23145127

Hingtgen SD, Kasmieh R, Elbayly E, Nesterenko I, Figueiredo JL, Dash R, Sarkar D, Hall D, Kozakov D, Vadja S, Fisher PB and Shah K. A first-generation multi-funtional cytokine for simultaneous optical tracking and tumor therapy. 2012 PLoS ONE. doi: 10.1371/journal.pone.0040234. PMID: 22808125


Kauer TM, Figueiredo JL, Hingtgen S, and Shah K. Encapsulated therapeutic stem cells implanted in the tumor resection cavity induce cell death in gliomas. 2012. Nature Neuroscience. 15: 197-204 doi: 10.1038/nn.3019. PMID: 22197831
Research Highlight: Drug Delivery: Flight, MH. Encapsulation improves therapeutic stem cell action, Nat. Review Drug Discovery 2012, 11, 106-107.

Shah K. In vivo imaging of the dynamics of different variants of EGFR in glioblastomas. Methods in Molecular Biology. 2011 doi: 10.1007/978-1-60761-901-7_11. PMID: 21153380

Shah K. Imaging fate of stem cells at a cellular resolution in the brains of mice. Methods in Molecular Biology. 2011 doi: 10.1007/978-1-60761-901-7_6. PMID: 21153375 

Bagci-Onder T, Wakimoto H, Anderegg M, Cameron C and Shah K. A dual PI3K/mTOR inhibitor, PI-103, cooperates with stem cell delivered TRAIL in experimental glioma models. Cancer Research. 2011 doi: 10.1158/0008-5472. PMID: 21084267 

Carney BJ and Shah K. Migration and fate of therapeutic stem cells in different brain disease models. Neuroscience. 2011 doi: 10.1016/j.neuroscience.2011.08.063. PMID: 21946010


Yoo BK, Chen D, Su ZZ, Gredler R, Yoo J, Shah K, Fisher PB and Sarkar D. Molecular Mechanism of Chemoresistance by Astrocyte Elevated Gene-1. Cancer Research. 2010 doi: 10.1158/0008-5472. PMID: 20388796

Van Eekelen M, Sasportas LS, Kasmieh R, Yip S, Figueiredo JL, Louis DN, Weissleder R and Shah K. Human stem cells expressing novel TSP-1 variant have anti-angiogenic effect on brain tumors. Oncogene. 2010 doi: 10.1038/onc.2010.75. PMID: 20305695

Hamed HA, Yacoub A, Park MA, Eulitt PJ, Dash R, Sarkar D, Dmitriev IP, Lesniak MS, Shah K, Grant S, Curiel DT, Fisher PB and Dent P. Inhibition of Multiple Protective Signaling Pathways and Ad.5/3 Delivery Enhances mda-7/IL-24 Therapy of Malignant Glioma. Molecular Therapy. 2010 doi: 10.1038/mt.2010.29. PMID: 20179672

Hingtgen SD, Kasmieh R, van de Water J, Weissleder R and Shah K. A Novel Molecule Integrating Therapeutic and Diagnostic Activities Reveals Multiple Aspects of Stem Cell-Based Therapy. Stem Cells. 2010 doi: 10.1002/stem.313. PMID: 20127797

Emdad L, Sarkar D, Lee SG, Su ZZ, Yoo BK, Dash R, Yacoub A, Fuller CE, Shah K, Dent P, Bruce JN and Fisher PB. Astrocyte elevated gene-1: a novel target for human glioma therapy. Molecular Cancer Therapeutics. 2010 doi: 10.1158/1535-7163. PMID: 20053777

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